Welcome to Palma Lab

Exploring mitochondria
to advance liver research

A translational research group investigating how mitochondrial plasticity, morphology, and dynamics shape cellular adaptation and maladaptation in liver health and disease.

What

Mapping Mitochondrial Morphology

We map mitochondrial shape, size, and organisation in human liver tissue to understand how organelle remodelling contributes to SLD, ALD, and cholangiocarcinoma.

How

Human ex vivo models

Developing patient-derived organotypic liver models and advanced imaging approaches to investigate mitochondrial plasticity directly in human tissue.

Why

Translational liver research

Bridging fundamental mitochondrial biology with clinically relevant human models to advance therapies for liver disease and cancer.

Who

Collaborative Team

A multidisciplinary team fostering openness, transparency, respect, strong work ethics, and shared ownership to drive rigorous and creative research.

Research

Our Projects

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Alcohol & Mitochondria

Ethanol driven mitochondrial remodelling

How ethanol reshapes mitochondrial architecture in hepatocytes in steatotic liver disease.

Mito Models

Human hepatic models to study mitochondria

Developing complex human models to investigate mitochondrial morphology and megamitochondria in the liver.

Drug Testing

Organotypic platforms for preclinical drug testing

Advancing organotypic liver models to evaluate novel therapeutic strategies for steatotic liver disease and liver cancer.

Mito Plasticty

Mitochondrial plasticity and organelle biology

Deciphering the fundamental principles governing mitochondrial plasticity in response to cellular signalling and metabolic stress.

Upcoming

Events

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23–26

May

2026

The Liver Sinusoid Meeting 2026

Tarragona, Spain

27–30

May

2026

EASL Congress 2026

Barcelona, Spain

20–22

Sep

2026

FEBS Advanced Course 2026

Spetses, Greece