Welcome to Palma Lab
Exploring mitochondria to advance liver research
A translational research programme on how mitochondrial plasticity, morphology, and dynamics shape cellular adaptation and maladaptation in liver health and disease.
What
Mapping Mitochondrial Morphology
We map mitochondrial shape, size, and organisation in human liver tissue to understand how organelle remodelling contributes to SLD, ALD, and cholangiocarcinoma.
How
Human ex vivo models
Developing patient-derived organotypic liver models and advanced imaging approaches to investigate mitochondrial plasticity directly in human tissue.
Why
Translational liver research
Bridging fundamental mitochondrial biology with clinically relevant human models to advance therapies for liver disease and cancer.
Who
Collaborative Team
A multidisciplinary team fostering openness, transparency, respect, strong work ethics, and shared ownership to drive rigorous and creative research.
Research
Research Projects
Ethanol driven mitochondrial remodelling
How ethanol reshapes mitochondrial architecture in hepatocytes in steatotic liver disease.
Human hepatic models to study mitochondria
Developing complex human models to investigate mitochondrial morphology and megamitochondria in the liver.
Organotypic platforms for preclinical drug testing
Advancing organotypic liver models to evaluate novel therapeutic strategies for steatotic liver disease and liver cancer.
Mitochondrial plasticity and organelle biology
Deciphering the fundamental principles governing mitochondrial plasticity in response to cellular signalling and metabolic stress.
Patient derived models of cholangiocarcinoma
Understanding how mitochondrial dynamics contribute to tumour progression in intrahepatic cholangiocarcinoma.
Talks & conferences