Publications

Comprehensive Analysis of Extracellular Matrix Remodelling via Cyclophilin Inhibition in Human Models of Alcohol-Related Liver Fibrosis

Rastovic U, Campinoti S, Wei L, Almeida B, Bozzano SF, Amiri R, Harris N, Ajayi O, Koay TS, Kerins C, et al.

British Journal of Pharmacology

Human Precision-Cut Liver Slices: A Potential Platform to Study Alcohol-Related Liver Disease

Rastovic U, Bozzano SF, Riva A, Simoni-Nieves A, Harris N, Miquel R, Lackner C, Zen Y, Zamalloa A, Menon K, et al.

International Journal of Molecular Sciences

Patient-Derived Precision Cut Tissue Slices from Primary Liver Cancer as a Potential Platform for Preclinical Drug Testing

Jagatia R, Doornebal EJ, Rastovic U, Harris N, Feyide M, Lyons AM, Miquel R, Zen Y, Zamalloa A, Malik F, et al.

eBioMedicine

Giant Mitochondria in Human Liver Disease

Shami GJ, Samarska IV, Koek GH, Li A, Palma E, Chokshi S, Wisse E, Braet F

Liver International

Human Immunocompetent Model of Neuroendocrine Liver Metastases Recapitulates Patient-Specific Tumour Microenvironment

Doornebal EJ, Harris N, Riva A, Jagatia R, Pizanias M, Prachalias A, Menon K, Preziosi M, Zamalloa A, Miquel R, et al.

Frontiers in Endocrinology

Extracellular Vesicle-Mediated Mitochondrial Reprogramming in Cancer

Carles-Fontana R, Heaton N, Palma E, Khorsandi SE

Cancers

Interplay between Cellular and Non-Cellular Components of the Tumour Microenvironment in Hepatocellular Carcinoma

Sükei T, Palma E, Urbani L

Cancers

Soluble TIM3 and Its Ligands Galectin-9 and CEACAM1 Are in Disequilibrium During Alcohol-Related Liver Disease and Promote Impairment of Anti-Bacterial Immunity

Riva A, Palma E, Devshi D, Corrigall D, Adams H, Heaton N, Menon K, Preziosi M, Zamalloa A, Miquel R, et al.

Frontiers in Physiology

Perturbations in Mitochondrial Dynamics Are Closely Involved in the Progression of Alcoholic Liver Disease

Palma E, Riva A, Moreno C, Odena G, Mudan S, Manyakin N, Miquel R, Degré D, Trepo E, Sancho-Bru P, et al.

Alcoholism: Clinical and Experimental Research

Dynamin-1-Like Protein Inhibition Drives Megamitochondria Formation as an Adaptive Response in Alcohol-Induced Hepatotoxicity

Palma E, Ma X, Riva A, Iansante V, Dhawan A, Wang S, Ni HM, Sesaki H, Williams R, Ding WX, et al.

American Journal of Pathology

Precision-Cut Liver Slices: A Versatile Tool to Advance Liver Research

Palma E, Doornebal EJ, Chokshi S

Hepatology International

Deficient IL-6/Stat3 Signaling, High TLR7, and Type I Interferons in Early Human Alcoholic Liver Disease: A Triad for Liver Damage and Fibrosis

Stärkel P, Schnabl B, Leclercq S, Komuta M, Bataller R, Argemi J, Palma E, Chokshi S, Hellerbrand C, Maccioni L, et al.

Hepatology Communications

Osteopontin Is a Proximal Effector of Leptin-Mediated Non-Alcoholic Steatohepatitis (NASH) Fibrosis

Coombes JD, Choi SS, Swiderska-Syn M, Manka P, Reid DT, Palma E, Briones-Orta MA, Xie G, Younis R, Kitamura N, et al.

Biochimica et Biophysica Acta

Blockade of PD1 and TIM3 Restores Innate and Adaptive Immunity in Patients with Acute Alcoholic Hepatitis

Markwick LJL, Riva A, Ryan JM, Cooksley H, Palma E, Tranah TH, Manakkat Vijay GK, Vergis N, Thursz M, Evans A, et al.

Gastroenterology

NIM811, a Cyclophilin Inhibitor without Immunosuppressive Activity, Is Beneficial in Collagen VI Congenital Muscular Dystrophy Models

Zulian A, Rizzo E, Schiavone M, Palma E, Tagliavini F, Blaauw B, Merlini L, Maraldi NM, Sabatelli P, Braghetta P, et al.

Human Molecular Genetics

Critical Evaluation of the Use of Cell Cultures for Inclusion in Clinical Trials of Patients Affected by Collagen VI Myopathies

Sabatelli P, Palma E, Angelin A, Squarzoni S, Urciuolo A, Pellegrini C, Tiepolo T, Bonaldo P, Gualandi F, Merlini L, et al.

Journal of Cellular Physiology

A Glutamine Synthetase Inhibitor Increases Survival and Decreases Cytokine Response in a Mouse Model of Acute Liver Failure

Jambekar AA, Palma E, Nicolosi L, Rasola A, Petronilli V, Chiara F, Bernardi P, Needleman R, Brusilow WSA

Liver International

Genetic Ablation of Cyclophilin D Rescues Mitochondrial Defects and Prevents Muscle Apoptosis in Collagen VI Myopathic Mice

Palma E, Tiepolo T, Angelin A, Sabatelli P, Maraldi NM, Basso E, Forte MA, Bernardi P, Bonaldo P

Human Molecular Genetics

The Cyclophilin Inhibitor Debio 025 Normalizes Mitochondrial Function, Muscle Apoptosis and Ultrastructural Defects in Col6a1-/- Myopathic Mice

Tiepolo T, Angelin A, Palma E, Sabatelli P, Merlini L, Nicolosi L, Finetti F, Braghetta P, Vuagniaux G, Dumont JM, et al.

British Journal of Pharmacology