Overview

Intrahepatic cholangiocarcinoma is an aggressive liver cancer with limited therapeutic options. Our research aims to advance and characterise human cholangiocarcinoma models that preserve key features of the tumour microenvironment and can be used to study mitochondrial behaviour in a more physiologically relevant context.

Using human tumour slice models and co-cultures with immune cells, we investigate how mitochondrial morphology and dynamics are altered in cholangiocarcinoma cells and how these changes may influence tumour adaptation, progression, and therapeutic response.

Objectives

• Advance human organotypic models of intrahepatic cholangiocarcinoma
• Characterise these models for the study of the tumour microenvironment
• Evaluate drug responses and therapeutic efficacy in human tumour models
• Refine these models for investigating mitochondrial morphology and dynamics