Overview

Mitochondria are dynamic organelles that continuously remodel their shape, size and organisation in response to cellular signalling and metabolic demands. These structural adaptations reflect the remarkable plasticity of mitochondria, which enables cells to respond to environmental and metabolic challenges. Our research aims to define the principles that regulate mitochondrial plasticity, with a particular focus on how signalling pathways and metabolic stressors influence mitochondrial architecture and function. Understanding how mitochondria adapt to stress will provide new insights into how mitochondrial structural changes contribute to cellular physiology and disease.

Objectives

• Define mitochondrial plasticity in response to metabolic and cellular stress signals
• Characterise how mitochondrial shape and size respond to signalling pathways
• Identify structural and functional signatures of mitochondrial adaptation
• Establish frameworks linking mitochondrial morphology to organelle function